| Pos | Name | Team | Pa | Ru | Rc | TD | 2Pt | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | RB | Josh Jacobs | UH | 0 | 1345 | 330 | 11 | 0 | 0 | 0 | 124 |
| 2. | RB | Derrick Henry | BuB | 4 | 1199 | 320 | 12 | 0 | 0 | 0 | 118 |
| RB | Austin Ekeler | CC | 0 | 634 | 623 | 13 | 0 | 0 | 0 | 118 | |
| 4. | RB | Nick Chubb | BB | 0 | 1153 | 172 | 12 | 1 | 0 | 0 | 116 |
| 5. | RB | Christian McCaffrey | MB | 34 | 819 | 593 | 10 | 0 | 0 | 0 | 106 |
| 6. | RB | Tony Pollard | BP | 0 | 760 | 184 | 11 | 0 | 0 | 0 | 96 |
| 7. | RB | Saquon Barkley | LFT | 0 | 1085 | 261 | 8 | 1 | 0 | 0 | 90 |
| 8. | RB | Dalvin Cook | MT | 0 | 950 | 170 | 9 | 0 | 0 | 0 | 84 |
| 9. | RB | Jamaal Williams | BuB | 0 | 672 | 25 | 10 | 1 | 0 | 0 | 82 |
| 10. | RB | Miles Sanders | LMM | 0 | 854 | 57 | 9 | 0 | 0 | 0 | 80 |
| 11. | RB | Aaron Jones | UH | 0 | 847 | 328 | 6 | 1 | 0 | 0 | 72 |
| 12. | RB | Ezekiel Elliott | AE | 0 | 716 | 73 | 9 | 0 | 0 | 0 | 70 |
| 13. | RB | Kenneth Walker III | SD | 0 | 504 | 102 | 8 | 0 | 0 | 0 | 66 |
| 14. | RB | Najee Harris | BP | 4 | 704 | 165 | 7 | 0 | 0 | 0 | 62 |
| RB | Dameon Pierce | MT | 0 | 939 | 165 | 5 | 0 | 0 | 0 | 62 | |
| 16. | RB | James Conner | CC | 0 | 561 | 200 | 6 | 0 | 0 | 0 | 60 |
| RB | Leonard Fournette | CR | 0 | 475 | 348 | 6 | 0 | 0 | 0 | 60 | |
| 18. | RB | Jeff Wilson Jr. | MHB | 0 | 692 | 149 | 5 | 0 | 0 | 0 | 54 |
| 19. | RB | Jonathan Taylor | BB | 0 | 861 | 130 | 4 | 0 | 0 | 0 | 52 |
| RB | D'Andre Swift | SD | 0 | 375 | 253 | 6 | 1 | 0 | 0 | 52 | |
| 21. | RB | Breece Hall | MT | 0 | 440 | 180 | 5 | 0 | 0 | 0 | 48 |
| 22. | RB | Devin Singletary | AO | 0 | 594 | 216 | 5 | 0 | 0 | 0 | 46 |
| RB | Alvin Kamara | BP | 0 | 550 | 433 | 3 | 0 | 0 | 0 | 46 | |
| 24. | RB | Rhamondre Stevenson | WG | 0 | 370 | 314 | 4 | 0 | 0 | 0 | 42 |
| 25. | RB | Joe Mixon | BuB | 0 | 548 | 266 | 3 | 0 | 0 | 0 | 40 |