| Pos | Name | Team | Week | Pass | Rush | Rec | TD | Conv | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | RB | Dalvin Cook | MT | 8/2020 | 0 | 163 | 63 | 4 | 0 | 0 | 0 | 32 |
| 2. | RB | Aaron Jones | UH | 2/2020 | 0 | 168 | 68 | 3 | 0 | 0 | 0 | 26 |
| 3. | RB | Derrick Henry | BuB | 12/2020 | 0 | 178 | 7 | 3 | 0 | 0 | 0 | 24 |
| RB | Joe Mixon | BuB | 4/2020 | 0 | 151 | 30 | 3 | 0 | 0 | 0 | 24 | |
| 5. | RB | Derrick Henry | BuB | 6/2020 | 0 | 212 | 52 | 2 | 0 | 0 | 0 | 22 |
| RB | Dalvin Cook | MT | 9/2020 | 0 | 206 | 46 | 2 | 0 | 0 | 0 | 22 | |
| RB | Antonio Gibson | UH | 12/2020 | 0 | 115 | 21 | 3 | 0 | 0 | 0 | 22 | |
| RB | Josh Jacobs | UH | 1/2020 | 0 | 93 | 46 | 3 | 0 | 0 | 0 | 22 | |
| 9. | RB | Alvin Kamara | AO | 10/2020 | 0 | 15 | 83 | 3 | 0 | 0 | 0 | 20 |
| 10. | RB | Kenyan Drake | BB | 6/2020 | 0 | 164 | 0 | 2 | 0 | 0 | 0 | 18 |
| RB | James Robinson | MB | 7/2020 | 0 | 119 | 18 | 2 | 1 | 0 | 0 | 18 | |
| RB | Alvin Kamara | AO | 2/2020 | 0 | 79 | 95 | 2 | 0 | 0 | 0 | 18 | |
| RB | Christian McCaffrey | MB | 9/2020 | 0 | 69 | 82 | 2 | 0 | 0 | 0 | 18 | |
| RB | Alvin Kamara | AO | 3/2020 | 0 | 58 | 139 | 2 | 0 | 0 | 0 | 18 | |
| 15. | RB | Dalvin Cook | MT | 4/2020 | 0 | 130 | 16 | 2 | 0 | 0 | 0 | 16 |
| RB | Nick Chubb | BB | 2/2020 | 0 | 124 | 9 | 2 | 0 | 0 | 0 | 16 | |
| RB | Derrick Henry | BuB | 3/2020 | 0 | 119 | 11 | 2 | 0 | 0 | 0 | 16 | |
| RB | D'Andre Swift | SD | 6/2020 | 0 | 116 | 7 | 2 | 0 | 0 | 0 | 16 | |
| RB | Ronald Jones | MHB | 6/2020 | 0 | 113 | 8 | 2 | 0 | 0 | 0 | 16 | |
| RB | Josh Jacobs | UH | 10/2020 | 0 | 112 | 24 | 2 | 0 | 0 | 0 | 16 | |
| RB | Nick Chubb | BB | 3/2020 | 0 | 108 | 2 | 2 | 0 | 0 | 0 | 16 | |
| RB | Melvin Gordon III | AE | 4/2020 | 0 | 107 | 11 | 2 | 0 | 0 | 0 | 16 | |
| RB | Leonard Fournette | CR | 2/2020 | 0 | 103 | 13 | 2 | 0 | 0 | 0 | 16 | |
| RB | Christian McCaffrey | MB | 1/2020 | 0 | 96 | 38 | 2 | 0 | 0 | 0 | 16 | |
| RB | Ezekiel Elliott | CC | 1/2020 | 0 | 96 | 31 | 2 | 0 | 0 | 0 | 16 |