| Pos | Name | Team | Week | Pass | Rush | Rec | TD | Conv | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | RB | Jonathan Taylor | BB | 11/2021 | 0 | 185 | 19 | 5 | 0 | 0 | 0 | 38 |
| 2. | QB | Justin Herbert | FM | 5/2021 | 398 | 29 | 0 | 5 | 1 | 0 | 0 | 36 |
| 3. | QB | Lamar Jackson | WG | 5/2021 | 442 | 62 | 0 | 4 | 2 | 0 | 0 | 35 |
| QB | Tom Brady | BP | 5/2021 | 411 | 13 | 0 | 5 | 0 | 0 | 0 | 35 | |
| QB | Patrick Mahomes | BuB | 10/2021 | 406 | 0 | 0 | 5 | 0 | 0 | 0 | 35 | |
| 6. | QB | Josh Allen | CR | 3/2021 | 358 | 9 | 0 | 5 | 0 | 0 | 0 | 34 |
| 7. | QB | Josh Allen | CR | 5/2021 | 315 | 59 | 0 | 4 | 0 | 0 | 0 | 30 |
| QB | Kyler Murray | BB | 1/2021 | 289 | 20 | 0 | 5 | 0 | 0 | 0 | 30 | |
| QB | Patrick Mahomes | BuB | 4/2021 | 278 | 26 | 0 | 5 | 0 | 0 | 0 | 30 | |
| QB | Tom Brady | BP | 2/2021 | 276 | 6 | 0 | 5 | 0 | 0 | 0 | 30 | |
| 11. | QB | Kyler Murray | BB | 2/2021 | 400 | 31 | 0 | 4 | 0 | 0 | 0 | 29 |
| 12. | QB | Aaron Rodgers | CC | 11/2021 | 385 | 21 | 0 | 4 | 0 | 0 | 0 | 28 |
| QB | Tom Brady | BP | 1/2021 | 379 | 0 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Tom Brady | BP | 8/2021 | 375 | 2 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Tom Brady | BP | 13/2021 | 368 | -1 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Matthew Stafford | LMM | 3/2021 | 343 | -2 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Aaron Rodgers | CC | 14/2021 | 341 | 0 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Patrick Mahomes | BuB | 1/2021 | 337 | 18 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Sam Darnold | MT | 4/2021 | 301 | 35 | 0 | 4 | 0 | 0 | 0 | 28 | |
| RB | Leonard Fournette | CR | 12/2021 | 0 | 100 | 31 | 4 | 0 | 0 | 0 | 28 | |
| RB | Aaron Jones | UH | 2/2021 | 0 | 67 | 48 | 4 | 0 | 0 | 0 | 28 | |
| RB | Austin Ekeler | LMM | 11/2021 | 0 | 50 | 65 | 4 | 0 | 0 | 0 | 28 | |
| 23. | QB | Josh Allen | CR | 14/2021 | 308 | 109 | 0 | 3 | 0 | 0 | 0 | 26 |
| QB | Justin Herbert | FM | 3/2021 | 281 | 16 | 0 | 4 | 1 | 0 | 0 | 26 | |
| QB | Kyler Murray | BB | 13/2021 | 123 | 59 | 0 | 4 | 0 | 0 | 0 | 26 |