| Pos | Name | Team | Pa | Ru | Rc | TD | 2Pt | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | RB | Jonathan Taylor | BB | 0 | 1348 | 336 | 18 | 0 | 0 | 0 | 166 |
| 2. | RB | Austin Ekeler | LMM | 0 | 730 | 535 | 16 | 1 | 0 | 0 | 138 |
| 3. | RB | James Conner | CC | 0 | 635 | 303 | 16 | 0 | 0 | 0 | 124 |
| 4. | RB | Joe Mixon | BuB | 0 | 1003 | 200 | 13 | 0 | 0 | 0 | 118 |
| 5. | RB | Derrick Henry | BuB | 5 | 937 | 154 | 11 | 1 | 0 | 0 | 104 |
| 6. | RB | Ezekiel Elliott | AE | 4 | 810 | 245 | 9 | 3 | 0 | 0 | 88 |
| 7. | RB | Aaron Jones | UH | 0 | 599 | 328 | 9 | 0 | 0 | 0 | 80 |
| 8. | RB | Dalvin Cook | MT | 0 | 978 | 202 | 6 | 2 | 0 | 0 | 78 |
| RB | Alvin Kamara | AO | 0 | 650 | 335 | 8 | 0 | 0 | 0 | 78 | |
| 10. | RB | Melvin Gordon III | CC | 0 | 716 | 166 | 9 | 0 | 0 | 0 | 76 |
| RB | Cordarrelle Patterson | LMM | 0 | 482 | 448 | 8 | 0 | 0 | 0 | 76 | |
| 12. | RB | Nick Chubb | BB | 0 | 926 | 112 | 7 | 0 | 0 | 0 | 74 |
| RB | Najee Harris | BP | 0 | 779 | 387 | 7 | 0 | 0 | 0 | 74 | |
| 14. | RB | Damien Harris | WG | 0 | 653 | 77 | 8 | 0 | 0 | 0 | 70 |
| RB | Darrell Henderson Jr. | MHB | 0 | 648 | 172 | 8 | 0 | 0 | 0 | 70 | |
| 16. | RB | James Robinson | MB | 0 | 682 | 209 | 7 | 0 | 0 | 0 | 66 |
| RB | D'Andre Swift | SD | 0 | 555 | 427 | 6 | 0 | 0 | 0 | 66 | |
| 18. | RB | Leonard Fournette | CR | 0 | 538 | 285 | 7 | 0 | 0 | 0 | 62 |
| 19. | RB | Antonio Gibson | UH | 0 | 772 | 207 | 5 | 1 | 0 | 0 | 60 |
| 20. | RB | Josh Jacobs | UH | 0 | 462 | 276 | 5 | 0 | 0 | 0 | 50 |
| 21. | RB | Elijah Mitchell | AO | 0 | 655 | 126 | 4 | 0 | 0 | 0 | 48 |
| RB | Kareem Hunt | WG | 0 | 366 | 175 | 5 | 1 | 0 | 0 | 48 | |
| 23. | RB | David Montgomery | FM | 0 | 608 | 172 | 4 | 0 | 0 | 0 | 46 |
| 24. | RB | Myles Gaskin | MT | 0 | 501 | 143 | 5 | 0 | 0 | 0 | 44 |
| 25. | RB | Javonte Williams | LMM | 0 | 442 | 147 | 4 | 0 | 0 | 0 | 40 |