| Pos | Name | Team | Week | Pass | Rush | Rec | TD | Conv | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | QB | Brett Favre | BB | 4/2005 | 303 | 12 | 0 | 4 | 2 | 0 | 0 | 32 |
| 2. | RB | LaDainian Tomlinson | CC | 3/2005 | 26 | 192 | 28 | 4 | 0 | 0 | 0 | 30 |
| 3. | QB | Jake Plummer | AO | 8/2005 | 309 | 22 | 0 | 4 | 0 | 0 | 0 | 28 |
| RB | Shaun Alexander | LMM | 6/2005 | 0 | 141 | 1 | 4 | 0 | 0 | 0 | 28 | |
| RB | Shaun Alexander | LMM | 3/2005 | 0 | 140 | 0 | 4 | 0 | 0 | 0 | 28 | |
| RB | LaDainian Tomlinson | CC | 9/2005 | 0 | 107 | 46 | 4 | 0 | 0 | 0 | 28 | |
| 7. | QB | Donovan McNabb | CC | 4/2005 | 369 | -1 | 0 | 3 | 1 | 0 | 0 | 24 |
| QB | Carson Palmer | MB | 12/2005 | 302 | 14 | 0 | 3 | 1 | 0 | 0 | 24 | |
| QB | Peyton Manning | UH | 4/2005 | 264 | 3 | 0 | 4 | 0 | 0 | 0 | 24 | |
| RB | LaDainian Tomlinson | CC | 12/2005 | 0 | 184 | 29 | 3 | 0 | 0 | 0 | 24 | |
| RB | Shaun Alexander | LMM | 10/2005 | 0 | 165 | 9 | 3 | 0 | 0 | 0 | 24 | |
| WR | Steve Smith | MB | 3/2005 | 0 | -2 | 170 | 3 | 0 | 0 | 0 | 24 | |
| 13. | QB | Ben Roethlisberger | FM | 13/2005 | 386 | 2 | 0 | 3 | 0 | 0 | 0 | 22 |
| QB | Peyton Manning | UH | 11/2005 | 365 | -3 | 0 | 3 | 0 | 0 | 0 | 22 | |
| QB | Tom Brady | BP | 5/2005 | 350 | 1 | 0 | 3 | 0 | 0 | 0 | 22 | |
| QB | Brett Favre | BB | 2/2005 | 342 | 19 | 0 | 3 | 0 | 0 | 0 | 22 | |
| QB | Jake Delhomme | LFT | 8/2005 | 341 | 2 | 0 | 3 | 0 | 0 | 0 | 22 | |
| QB | Carson Palmer | MB | 2/2005 | 337 | 3 | 0 | 3 | 0 | 0 | 0 | 22 | |
| QB | Drew Brees | CC | 8/2005 | 324 | 1 | 0 | 3 | 0 | 0 | 0 | 22 | |
| QB | Peyton Manning | UH | 9/2005 | 321 | 24 | 0 | 3 | 0 | 0 | 0 | 22 | |
| QB | Daunte Culpepper | LMM | 3/2005 | 300 | 36 | 0 | 3 | 0 | 0 | 0 | 22 | |
| RB | LaDainian Tomlinson | CC | 6/2005 | 4 | 140 | 39 | 3 | 0 | 0 | 0 | 22 | |
| RB | Edgerrin James | MT | 6/2005 | 0 | 143 | 16 | 3 | 0 | 0 | 0 | 22 | |
| RB | LaMont Jordan | MHB | 7/2005 | 0 | 122 | 40 | 3 | 0 | 0 | 0 | 22 | |
| RB | Mike Anderson | MHB | 11/2005 | 0 | 113 | 16 | 3 | 0 | 0 | 0 | 22 |