| Pos | Name | Team | Week | Pass | Rush | Rec | TD | Conv | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | QB | Mike Vick | AE | 10/2010 | 333 | 80 | 0 | 6 | 0 | 0 | 0 | 42 |
| 2. | QB | Peyton Manning | BuB | 11/2010 | 396 | 0 | 0 | 4 | 0 | 0 | 0 | 28 |
| QB | Drew Brees | LFT | 11/2010 | 382 | 0 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Tom Brady | BP | 10/2010 | 350 | 3 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Tom Brady | BP | 12/2010 | 341 | 1 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Tom Brady | BP | 13/2010 | 326 | 3 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Eli Manning | BB | 7/2010 | 306 | -1 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Aaron Rodgers | SD | 11/2010 | 301 | 21 | 0 | 4 | 0 | 0 | 0 | 28 | |
| 9. | QB | Ben Roethlisberger | FM | 11/2010 | 275 | 55 | 0 | 4 | 0 | 0 | 0 | 26 |
| QB | Matthew Stafford | LMM | 8/2010 | 212 | 0 | 0 | 4 | 1 | 0 | 0 | 26 | |
| RB | Arian Foster | UH | 1/2010 | 0 | 231 | 7 | 3 | 0 | 0 | 0 | 26 | |
| RB | Jahvid Best | UH | 2/2010 | 0 | 78 | 154 | 3 | 0 | 0 | 0 | 26 | |
| WR | Kenny Britt | LFT | 7/2010 | 0 | 0 | 225 | 3 | 0 | 0 | 0 | 26 | |
| 14. | QB | Kyle Orton | LMM | 10/2010 | 296 | -1 | 0 | 4 | 0 | 0 | 0 | 24 |
| QB | Philip Rivers | CC | 9/2010 | 295 | -7 | 0 | 4 | 0 | 0 | 0 | 24 | |
| QB | Jay Cutler | MHB | 12/2010 | 247 | 17 | 0 | 4 | 0 | 0 | 0 | 24 | |
| QB | Philip Rivers | CC | 11/2010 | 233 | 6 | 0 | 4 | 0 | 0 | 0 | 24 | |
| RB | Peyton Hillis | MT | 12/2010 | 0 | 131 | 63 | 3 | 0 | 0 | 0 | 24 | |
| WR | Dwayne Bowe | MT | 12/2010 | 0 | 0 | 170 | 3 | 0 | 0 | 0 | 24 | |
| WR | Greg Jennings | BP | 11/2010 | 0 | 0 | 152 | 3 | 0 | 0 | 0 | 24 | |
| 21. | QB | Matt Schaub | MT | 2/2010 | 497 | 2 | 0 | 3 | 0 | 0 | 0 | 23 |
| QB | Peyton Manning | BuB | 1/2010 | 433 | 0 | 0 | 3 | 0 | 0 | 0 | 23 | |
| QB | Carson Palmer | MB | 7/2010 | 412 | 0 | 0 | 3 | 0 | 0 | 0 | 23 | |
| QB | Tony Romo | AE | 5/2010 | 406 | 9 | 0 | 3 | 0 | 0 | 0 | 23 | |
| 25. | QB | Ben Roethlisberger | FM | 10/2010 | 387 | 12 | 0 | 3 | 0 | 0 | 0 | 22 |