| Pos | Name | Team | Week | Pass | Rush | Rec | TD | Conv | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | RB | Doug Martin | BuB | 9/2012 | 0 | 251 | 21 | 4 | 0 | 0 | 0 | 34 |
| 2. | RB | Shonn Greene | MHB | 6/2012 | 0 | 161 | 0 | 3 | 0 | 0 | 0 | 24 |
| 3. | RB | Doug Martin | BuB | 8/2012 | 0 | 135 | 79 | 2 | 0 | 0 | 0 | 20 |
| RB | Mikel Leshoure | MHB | 9/2012 | 0 | 70 | 0 | 3 | 0 | 0 | 0 | 20 | |
| 5. | RB | Chris Johnson | CR | 7/2012 | 0 | 195 | 3 | 2 | 0 | 0 | 0 | 18 |
| RB | Adrian Peterson | WG | 9/2012 | 0 | 182 | 11 | 2 | 0 | 0 | 0 | 18 | |
| RB | Bryce Brown | CC | 12/2012 | 0 | 178 | 11 | 2 | 0 | 0 | 0 | 18 | |
| RB | Reggie Bush | AE | 2/2012 | 0 | 172 | 25 | 2 | 0 | 0 | 0 | 18 | |
| RB | Bryce Brown | CC | 13/2012 | 0 | 169 | 14 | 2 | 0 | 0 | 0 | 18 | |
| RB | C.J. Spiller | FM | 2/2012 | 0 | 123 | 47 | 2 | 0 | 0 | 0 | 18 | |
| 11. | RB | Jamaal Charles | MB | 3/2012 | 0 | 233 | 55 | 1 | 0 | 0 | 0 | 16 |
| RB | Andre Brown | UH | 3/2012 | 0 | 113 | 17 | 2 | 0 | 0 | 0 | 16 | |
| RB | Willis McGahee | AO | 2/2012 | 0 | 113 | 11 | 2 | 0 | 0 | 0 | 16 | |
| RB | Trent Richardson | AE | 2/2012 | 0 | 109 | 36 | 2 | 0 | 0 | 0 | 16 | |
| RB | Stevan Ridley | FM | 4/2012 | 0 | 106 | 0 | 2 | 0 | 0 | 0 | 16 | |
| RB | Arian Foster | UH | 12/2012 | 0 | 102 | 15 | 2 | 0 | 0 | 0 | 16 | |
| RB | Arian Foster | UH | 7/2012 | 0 | 98 | 5 | 2 | 0 | 0 | 0 | 16 | |
| RB | Jamaal Charles | MB | 4/2012 | 0 | 92 | 23 | 2 | 0 | 0 | 0 | 16 | |
| RB | Fred Jackson | MB | 10/2012 | 0 | 80 | 35 | 2 | 0 | 0 | 0 | 16 | |
| RB | Ray Rice | LMM | 6/2012 | 0 | 63 | 43 | 2 | 0 | 0 | 0 | 16 | |
| 21. | RB | Adrian Peterson | WG | 13/2012 | 0 | 210 | 10 | 1 | 0 | 0 | 0 | 14 |
| RB | Ahmad Bradshaw | MT | 5/2012 | 0 | 200 | 29 | 1 | 0 | 0 | 0 | 14 | |
| RB | Adrian Peterson | WG | 10/2012 | 0 | 171 | 5 | 1 | 1 | 0 | 0 | 14 | |
| RB | Alfred Morris | BP | 1/2012 | 0 | 96 | 0 | 2 | 0 | 0 | 0 | 14 | |
| RB | Arian Foster | UH | 1/2012 | 0 | 79 | -4 | 2 | 0 | 0 | 0 | 14 |