| Pos | Name | Team | Week | Pass | Rush | Rec | TD | Conv | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | QB | Patrick Mahomes | BuB | 1/2022 | 360 | 5 | 0 | 5 | 0 | 0 | 0 | 34 |
| QB | Lamar Jackson | WG | 3/2022 | 218 | 107 | 0 | 5 | 0 | 0 | 0 | 34 | |
| 3. | QB | Jared Goff | MB | 4/2022 | 378 | 1 | 0 | 4 | 2 | 0 | 0 | 32 |
| QB | Lamar Jackson | WG | 2/2022 | 318 | 119 | 0 | 4 | 0 | 0 | 0 | 32 | |
| QB | Justin Fields | LFT | 9/2022 | 123 | 178 | 0 | 4 | 1 | 0 | 0 | 32 | |
| 6. | QB | Joe Burrow | MHB | 7/2022 | 481 | 20 | 0 | 4 | 0 | 0 | 0 | 29 |
| QB | Josh Allen | CR | 5/2022 | 424 | 42 | 0 | 4 | 0 | 0 | 0 | 29 | |
| 8. | QB | Jalen Hurts | CC | 13/2022 | 380 | 12 | 0 | 4 | 0 | 0 | 0 | 28 |
| QB | Trevor Lawrence | SD | 14/2022 | 368 | 7 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Joe Burrow | MHB | 11/2022 | 355 | 5 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Patrick Mahomes | BuB | 10/2022 | 331 | 39 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Josh Allen | CR | 2/2022 | 317 | 10 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Joe Burrow | MHB | 6/2022 | 300 | 25 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Justin Fields | LFT | 10/2022 | 167 | 147 | 0 | 4 | 0 | 0 | 0 | 28 | |
| 15. | QB | Josh Allen | CR | 1/2022 | 297 | 56 | 0 | 4 | 0 | 0 | 0 | 26 |
| 16. | QB | Jalen Hurts | CC | 2/2022 | 333 | 57 | 0 | 3 | 0 | 0 | 0 | 24 |
| QB | Trevor Lawrence | SD | 12/2022 | 321 | 1 | 0 | 3 | 1 | 0 | 0 | 24 | |
| QB | Patrick Mahomes | BuB | 5/2022 | 292 | 28 | 0 | 4 | 0 | 0 | 0 | 24 | |
| QB | Jalen Hurts | CC | 8/2022 | 285 | 10 | 0 | 4 | 0 | 0 | 0 | 24 | |
| QB | Jared Goff | MB | 2/2022 | 256 | -2 | 0 | 4 | 0 | 0 | 0 | 24 | |
| 21. | QB | Patrick Mahomes | BuB | 7/2022 | 423 | 0 | 0 | 3 | 0 | 0 | 0 | 23 |
| 22. | QB | Tom Brady | BP | 4/2022 | 385 | 0 | 0 | 3 | 0 | 0 | 0 | 22 |
| QB | Tua Tagovailoa | BuB | 8/2022 | 382 | 19 | 0 | 3 | 0 | 0 | 0 | 22 | |
| QB | Geno Smith | MT | 13/2022 | 367 | 3 | 0 | 3 | 0 | 0 | 0 | 22 | |
| QB | Patrick Mahomes | BuB | 14/2022 | 352 | -3 | 0 | 3 | 0 | 0 | 0 | 22 |