| Pos | Name | Team | Week | Pass | Rush | Rec | TD | Conv | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | RB | Josh Jacobs | UH | 12/2022 | 0 | 229 | 74 | 2 | 0 | 0 | 0 | 24 |
| RB | Josh Jacobs | UH | 7/2022 | 0 | 143 | 12 | 3 | 0 | 0 | 0 | 24 | |
| RB | D'Onta Foreman | BB | 8/2022 | 0 | 118 | 0 | 3 | 1 | 0 | 0 | 24 | |
| RB | Alvin Kamara | AO | 8/2022 | 0 | 62 | 96 | 3 | 0 | 0 | 0 | 24 | |
| 5. | RB | Christian McCaffrey | MB | 8/2022 | 34 | 94 | 55 | 3 | 0 | 0 | 0 | 22 |
| RB | Tony Pollard | BP | 8/2022 | 0 | 131 | 16 | 3 | 0 | 0 | 0 | 22 | |
| RB | Nick Chubb | BB | 2/2022 | 0 | 87 | 26 | 3 | 0 | 0 | 0 | 22 | |
| RB | Austin Ekeler | LMM | 4/2022 | 0 | 60 | 49 | 3 | 0 | 0 | 0 | 22 | |
| 9. | RB | Derrick Henry | BuB | 8/2022 | 0 | 219 | 9 | 2 | 0 | 0 | 0 | 20 |
| RB | Jamaal Williams | BuB | 11/2022 | 0 | 64 | 0 | 3 | 0 | 0 | 0 | 20 | |
| 11. | RB | Austin Ekeler | LMM | 5/2022 | 0 | 173 | 26 | 2 | 0 | 0 | 0 | 18 |
| RB | Kenneth Walker III | SD | 7/2022 | 0 | 168 | 0 | 2 | 0 | 0 | 0 | 18 | |
| RB | Josh Jacobs | UH | 4/2022 | 0 | 144 | 31 | 2 | 0 | 0 | 0 | 18 | |
| RB | Miles Sanders | LMM | 14/2022 | 0 | 144 | 11 | 2 | 0 | 0 | 0 | 18 | |
| RB | Miles Sanders | LMM | 12/2022 | 0 | 143 | 17 | 2 | 0 | 0 | 0 | 18 | |
| RB | Aaron Jones | UH | 2/2022 | 0 | 132 | 38 | 2 | 0 | 0 | 0 | 18 | |
| RB | Christian McCaffrey | MB | 14/2022 | 0 | 119 | 34 | 2 | 0 | 0 | 0 | 18 | |
| RB | Nick Chubb | BB | 8/2022 | 0 | 101 | 3 | 2 | 1 | 0 | 0 | 18 | |
| RB | Tony Pollard | BP | 11/2022 | 0 | 80 | 109 | 2 | 0 | 0 | 0 | 18 | |
| 20. | RB | Derrick Henry | BuB | 11/2022 | 4 | 87 | 45 | 2 | 0 | 0 | 0 | 16 |
| RB | Nick Chubb | BB | 5/2022 | 0 | 134 | 0 | 2 | 0 | 0 | 0 | 16 | |
| RB | Derrick Henry | BuB | 9/2022 | 0 | 115 | 0 | 2 | 0 | 0 | 0 | 16 | |
| RB | Kenneth Walker III | SD | 9/2022 | 0 | 109 | 20 | 2 | 0 | 0 | 0 | 16 | |
| RB | Travis Etienne Jr. | BuB | 9/2022 | 0 | 109 | 17 | 2 | 0 | 0 | 0 | 16 | |
| RB | Jamaal Williams | BuB | 4/2022 | 0 | 108 | 1 | 2 | 0 | 0 | 0 | 16 |